A structural role for hormone in the thyroid hormone receptor

  title={A structural role for hormone in the thyroid hormone receptor},
  author={Richard L. Wagner and James W. Apriletti and Mary E. McGrath and Brian L West and J. D. Baxter and Robert Fletterick},
The crystal structure of the rat aα thyroid hormone receptor ligand-binding domain bound with a thyroid hormone agonist reveals that ligand is completely buried within the domain as part of the hydrophobic core. In addition, the carboxy-terminal activation domain forms an amphi-pathic helix, with its hydrophobic face constituting part of the hormone binding cavity. These observations suggest a structural role for ligand, in establishing the active conformation of the receptor, that is likely to… CONTINUE READING
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