A structural role for hormone in the thyroid hormone receptor

@article{Wagner1995ASR,
  title={A structural role for hormone in the thyroid hormone receptor},
  author={Richard L. Wagner and James W. Apriletti and Mary E. McGrath and Brian L West and J. D. Baxter and Robert Fletterick},
  journal={Nature},
  year={1995},
  volume={378},
  pages={690-697}
}
The crystal structure of the rat aα thyroid hormone receptor ligand-binding domain bound with a thyroid hormone agonist reveals that ligand is completely buried within the domain as part of the hydrophobic core. In addition, the carboxy-terminal activation domain forms an amphi-pathic helix, with its hydrophobic face constituting part of the hormone binding cavity. These observations suggest a structural role for ligand, in establishing the active conformation of the receptor, that is likely to… CONTINUE READING
Highly Influential
This paper has highly influenced 19 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS