A structural perspective on the interaction between lipopolysaccharide and factor C, a receptor involved in recognition of Gram-negative bacteria.

@article{Koshiba2007ASP,
  title={A structural perspective on the interaction between lipopolysaccharide and factor C, a receptor involved in recognition of Gram-negative bacteria.},
  author={Takumi Koshiba and Tomoyuki Hashii and Shun-ichiro Kawabata},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 6},
  pages={3962-7}
}
The recognition of broadly conserved microorganism components known as pathogen-associated molecular patterns is an essential step in initiating the innate immune response. In the horseshoe crab, stimulation of hemocytes with lipopolysaccharide (LPS) causes the activation of its innate immune response, and Factor C, a serine protease zymogen, plays an important role in this event. Here, we report that Factor C associates with LPS on the hemocyte surface and directly recognizes Gram-negative… CONTINUE READING

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