A structural motif in the variant surface glycoproteins of Trypanosoma brucei

Abstract

The variable domain of the trypanosome variant surface glycoprotein (VSG) ILTat 1.24 has been shown by X-ray crystallography to resemble closely the structures of VSG MITat 1.2, despite their low sequence similarity. Specific structural features of these VSGs, including substitution of carbohydrate for an α-helix, can be found in other VSG sequences. Thus… (More)
DOI: 10.1038/362603a0

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