A structural motif in the variant surface glycoproteins of Trypanosoma brucei

@article{Blum1993ASM,
  title={A structural motif in the variant surface glycoproteins of Trypanosoma brucei},
  author={Michael L. Blum and James A. Down and Anne M. Gurnett and Mark Carrington and Mervyn J. Turner and Don C. Wiley},
  journal={Nature},
  year={1993},
  volume={362},
  pages={603-609}
}
  • Michael L. Blum, James A. Down, +3 authors Don C. Wiley
  • Published 1993
  • Biology, Medicine
  • Nature
  • The variable domain of the trypanosome variant surface glycoprotein (VSG) ILTat 1.24 has been shown by X-ray crystallography to resemble closely the structures of VSG MITat 1.2, despite their low sequence similarity. Specific structural features of these VSGs, including substitution of carbohydrate for an α-helix, can be found in other VSG sequences. Thus antigenic variation in trypanosomes is accomplished by sequence variation, not gross structural alteration; the extensive sequence… CONTINUE READING

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