A structural model for the catalytic cycle of Ca(2+)-ATPase.

  title={A structural model for the catalytic cycle of Ca(2+)-ATPase.},
  author={Chen Xu and William J Rice and Wanzhong He and David L. Stokes},
  journal={Journal of molecular biology},
  volume={316 1},
Ca(2+)-ATPase is responsible for active transport of calcium ions across the sarcoplasmic reticulum membrane. This coupling involves an ordered sequence of reversible reactions occurring alternately at the ATP site within the cytoplasmic domains, or at the calcium transport sites within the transmembrane domain. These two sites are separated by a large distance and conformational changes have long been postulated to play an important role in their coordination. To characterize the nature of… 

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