A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation.

  title={A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation.},
  author={Tracey A Dobbs and John A. Tainer and Susan P Lees-Miller},
  journal={DNA repair},
  volume={9 12},
The DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and Ku heterodimer together form the biologically critical DNA-PK complex that plays key roles in the repair of ionizing radiation-induced DNA double-strand breaks through the non-homologous end-joining (NHEJ) pathway. Despite elegant and informative electron microscopy studies, the mechanism by which DNA-PK co-ordinates the initiation of NHEJ has been enigmatic due to limited structural information. Here, we discuss how the recently… CONTINUE READING
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