A structural model for multimodular NRPS assembly lines.

  title={A structural model for multimodular NRPS assembly lines.},
  author={Mohamed A. Marahiel},
  journal={Natural product reports},
  volume={33 2},
This viewpoint article focuses on the structures of the dissected catalytic domains of non-ribosomal peptide synthetases (NRPSs) associated with substrate selection and activation (A domain), substrate shuttling among the active sites (PCP domain), peptide bond formation (C domain) and product release (TE domain). Structural details of these essential components of the NRPS machinery, integrated in a didomain (PCP-C) and an elongation module (C-A-PCP), were used to generate a model for a… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 12 extracted citations

Similar Papers

Loading similar papers…