A structural model for glutathione-complexed iron-sulfur cluster as a substrate for ABCB7-type transporters.

@article{Qi2014ASM,
  title={A structural model for glutathione-complexed iron-sulfur cluster as a substrate for ABCB7-type transporters.},
  author={Wenbin Qi and Jingwei Li and James Allan Cowan},
  journal={Chemical communications},
  year={2014},
  volume={50 29},
  pages={3795-8}
}
Glutathione-complexed [2Fe-2S] cluster is shown to significantly stimulate the ATPase activity of an ABCB7-type transporter in both solution and proteoliposome-bound forms (KD ∼ 68 μM). The cluster is a likely natural substrate for this transporter, which has been implicated in cytosolic Fe-S cluster protein maturation. A possible substrate-binding site is identified on a new structural model for the active transporter. 

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Enzyme Kinetics. Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme

I. H. Segel
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