A structural model for K2P potassium channels based on 23 pairs of interacting sites and continuum electrostatics

@inproceedings{Kollewe2009ASM,
  title={A structural model for K2P potassium channels based on 23 pairs of interacting sites and continuum electrostatics},
  author={Astrid Kollewe and Albert Y Lau and Ashley Sullivan and Beno{\^i}t Roux and Steve A. N. Goldstein},
  booktitle={The Journal of general physiology},
  year={2009}
}
K(2P)Ø, the two-pore domain potassium background channel that determines cardiac rhythm in Drosophila melanogaster, and its homologues that establish excitable membrane activity in mammals are of unknown structure. K(2P) subunits have two pore domains flanked by transmembrane (TM) spans: TM1-P1-TM2-TM3-P2-TM4. To establish spatial relationships in K(2P)Ø, we identified pairs of sites that display electrostatic compensation. Channels silenced by the addition of a charge in pore loop 1 (P1) or P2… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

K(+) channels: function-structural overview.

Comprehensive Physiology • 2012
View 3 Excerpts

References

Publications referenced by this paper.
Showing 1-10 of 62 references

X-ray structure of a voltage-dependent K+ channel

Nature • 2003
View 4 Excerpts
Highly Influenced

Is arginine charged in a membrane?

View 3 Excerpts
Highly Influenced

The determinants of pKas in proteins

A. Sali
2001
View 3 Excerpts
Highly Influenced

Assignment of the human weak inward rectifier K + channel TWIK - 1 gene to chromosome 1 q 42 - q 43

L. Li, I. Vorobyov, A. D. MacKerell, T. W. Allen
Genomics . • 2008
View 1 Excerpt

Similar Papers

Loading similar papers…