A structural explanation of the effects of dissociated glucocorticoids on glucocorticoid receptor transactivation.

Abstract

There is a therapeutic need for glucocorticoid receptor (GR) ligands that distinguish between the transrepression and transactivation activity of the GR, the later thought to be responsible for side effects. These ligands are known as "dissociated glucocorticoids" (dGCs). The first published dGCs, RU24782 (9α-fluoro-11β-hydroxy-16α-methylpregna-21… (More)
DOI: 10.1124/mol.113.085860

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