A structural basis for the reduced toxicity of dinophysistoxin-2.

@article{Huhn2009ASB,
  title={A structural basis for the reduced toxicity of dinophysistoxin-2.},
  author={Jason Huhn and Philip D. Jeffrey and K. J. Larsen and Thomas Rundberget and Frode Rise and Neil R Cox and Vickery L Arcus and Yigong Shi and Christopher O Miles},
  journal={Chemical research in toxicology},
  year={2009},
  volume={22 11},
  pages={
          1782-6
        }
}
Okadaic acid (OA), dinophysistoxin-1 (DTX-1), and dinophysistoxin-2 (DTX-2) are algal toxins that can accumulate in shellfish and cause diarrhetic shellfish poisoning. Recent studies indicate that DTX-2 is about half as toxic and has about half the affinity for protein phosphatase 2A (PP2A) as OA. NMR structural studies showed that DTX-1 possessed an equatorial 35-methyl group but that DTX-2 had an axial 35-methyl group. Molecular modeling studies indicated that an axial 35-methyl could exhibit… CONTINUE READING

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