A structural basis for depolymerization of alginate by polysaccharide lyase family-7.

@article{Yamasaki2005ASB,
  title={A structural basis for depolymerization of alginate by polysaccharide lyase family-7.},
  author={M Yamasaki and Kohei Ogura and Wataru Hashimoto and Bunzo Mikami and Kousaku Murata},
  journal={Journal of molecular biology},
  year={2005},
  volume={352 1},
  pages={11-21}
}
Alginate lyases depolymerize alginate, a heteropolysaccharide consisting of alpha-L-guluronate and beta-D-mannuronate, through a beta-elimination reaction. Their structure/function relationships are expected to provide information valuable to future industrial alginate processing and drug design for Pseudomonas aeruginosa alginate biofilm-dependent infection, but much remains unknown. Here, we present the crystal structure at 1.0 A resolution and the results of mutational analysis of… CONTINUE READING
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