A structural approach to the role of CCN (CYR61/CTGF/NOV) proteins in tumourigenesis

Abstract

The CCN (C YR61 [Cystein-rich61]/C TGF [connective tissue growth factor]/N OV [Nephroblastoma overexpressed]) proteins constitute a family of regulatory factors involved in many aspects of cell proliferation and differentiation. An increasing body of evidence indicates that abnormal expression of the CCN proteins is associated to tumourgenesis. The… (More)
DOI: 10.1186/1475-2867-3-15

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