A structural and pharmacological study of alkaloids of Vinca Minor

@article{Smeyers1991ASA,
  title={A structural and pharmacological study of alkaloids of Vinca Minor},
  author={Yves G. Smeyers and N. J. Smeyers and Juan J. R{\'a}ndez and Alfonso Hern{\'a}ndez-Laguna and Enrique G{\'a}lvez-ruano},
  journal={Molecular Engineering},
  year={1991},
  volume={1},
  pages={153-160}
}
The three-dimensional structures of five indole alkaloids of Vinca (Vincamine, Vincamone, Apovincamine, Vincaminol, and Desoxyvincaminol) are determined theoretically and compared with the available experimental data. The main frame of all these compounds presents a similar structure: planar for the indole moiety, and pan-shaped centered on the C-3 atom for the second moiety. From this central atom a particularly active hydrogen atom points downwards. The main structural parameters obtained… 
Non-alkaloid constituents of Vinca major.
TLDR
One new iridoid glycoside (compound 1), together with 11 known compounds, were isolated from Vinca major, and it is concluded that compound 1 is a newly identified iridoids glycosides with moderate antioxidant activity.
Analysis of Vicamine Using High Performance Liquid Chromatography and Antioxidant Activity of Vincaminor Extract
Vincamine, one of the major indole alkaloids in vincaminor (Vinca minor L.) is commonly used for treating cerebrovascular diseases. The antioxidant activity of vincaminor extracts and vincamine were
l-tryptophan decarboxylase activity and tryptamine accumulation in callus cultures of Vinca minor L.
TLDR
During later stages of callus culture growth cycle, an increase in TDC activity was observed, and this activity depended on culture conditions and age ofcallus cultures, and in addition, TDCactivity and tryptamine accumulation in callus cultures were strongly enhanced by light treatment.
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