A striking common O-linked N-acetylglucosaminyl moiety between cruzipain and myosin.

@article{Acosta2011ASC,
  title={A striking common O-linked N-acetylglucosaminyl moiety between cruzipain and myosin.},
  author={Diana Maria Castillo Acosta and Luciana L{\'i}a Soprano and M. Montserrat Real Ferrero and Malena Landoni and M{\'o}nica In{\'e}s Esteva and Alicia S Couto and Vilma Gladys Duschak},
  journal={Parasite immunology},
  year={2011},
  volume={33 7},
  pages={
          363-70
        }
}
Single units of O-linked N-acetylglucosamine (GlcNAc), usually components of nuclear and cytoplasmatic proteins, are present at the C-terminal domain of cruzipain (Cz), a lysosomal major antigen from Trypanosoma cruzi. On the other hand, antibodies directed against some self-antigens like myosin are associated with Chagas heart disease. The participation of O-GlcNAc moieties in the molecular antigenicity of Cz was determined using GlcNAc linked to aprotinin by ELISA. The immune cross-reactivity… CONTINUE READING
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