A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity

@article{Yao2015ASI,
  title={A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity},
  author={Y. Yao and Xiaotian Cui and Ismael Al‐Ramahi and Xiaoli Sun and B. Li and Jiapeng Hou and M. DiFiglia and J. Palacino and Z. Wu and Lixiang Ma and J. Botas and B. Lu},
  journal={eLife},
  year={2015},
  volume={4}
}
Huntington's disease (HD) represents an important model for neurodegenerative disorders and proteinopathies. It is mainly caused by cytotoxicity of the mutant huntingtin protein (Htt) with an expanded polyQ stretch. While Htt is ubiquitously expressed, HD is characterized by selective neurodegeneration of the striatum. Here we report a striatal-enriched orphan G protein-coupled receptor(GPCR) Gpr52 as a stabilizer of Htt in vitro and in vivo. Gpr52 modulates Htt via cAMP-dependent but PKA… Expand
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