A stress-responsive system for mitochondrial protein degradation.

  title={A stress-responsive system for mitochondrial protein degradation.},
  author={Jin-Mi Heo and Nurit Livnat-Levanon and Eric B. Taylor and Kevin T. Jones and Noah Dephoure and Julia Ring and Jianxin Xie and Jeffrey L Brodsky and Frank Madeo and Steven P Gygi and Kaveh Ashrafi and Michael H. Glickman and Jared Rutter},
  journal={Molecular cell},
  volume={40 3},
We show that Ydr049 (renamed VCP/Cdc48-associated mitochondrial stress-responsive--Vms1), a member of an unstudied pan-eukaryotic protein family, translocates from the cytosol to mitochondria upon mitochondrial stress. Cells lacking Vms1 show progressive mitochondrial failure, hypersensitivity to oxidative stress, and decreased chronological life span. Both yeast and mammalian Vms1 stably interact with Cdc48/VCP/p97, a component of the ubiquitin/proteasome system with a well-defined role in… CONTINUE READING


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