A strategy to discover decoy chemokine ligands with an anti-inflammatory activity

@inproceedings{Abboud2015AST,
  title={A strategy to discover decoy chemokine ligands with an anti-inflammatory activity},
  author={Dayana Abboud and François Daubeuf and Quoc Do and Val{\'e}rie Utard and Pascal Villa and Jacques Haiech and Dominique Bonnet and Marcel Hibert and Philippe Bernard and J Galzi and Nelly Frossard},
  booktitle={Scientific reports},
  year={2015}
}
Excessive signaling by chemokines has been associated with chronic inflammation or cancer, thus attracting substantial attention as promising therapeutic targets. Inspired by chemokine-clearing molecules shaped by pathogens to escape the immune system, we designed a generic screening assay to discover chemokine neutralizing molecules (neutraligands) and unambiguously distinguish them from molecules that block the receptor (receptor antagonists). This assay, called TRIC-r, combines time-resolved… CONTINUE READING
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