A strategy to determine operating parameters in tissue engineering hollow fiber bioreactors

@inproceedings{Shipley2011AST,
  title={A strategy to determine operating parameters in tissue engineering hollow fiber bioreactors},
  author={R Wayne Shipley and AJ Davidson and K Chan and JB Chaudhuri and SL Waters and MJ Ellis},
  booktitle={Biotechnology and bioengineering},
  year={2011}
}
The development of tissue engineering hollow fiber bioreactors (HFB) requires the optimal design of the geometry and operation parameters of the system. This article provides a strategy for specifying operating conditions for the system based on mathematical models of oxygen delivery to the cell population. Analytical and numerical solutions of these models are developed based on Michaelis-Menten kinetics. Depending on the minimum oxygen concentration required to culture a functional cell… CONTINUE READING
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