A strategy to analyze the phenotypic consequences of inhibiting the association of an RNA-binding protein with a specific RNA.

@article{Cibois2010AST,
  title={A strategy to analyze the phenotypic consequences of inhibiting the association of an RNA-binding protein with a specific RNA.},
  author={Marie Cibois and Carole Gautier-Courteille and Audrey Vallée and Luc Paillard},
  journal={RNA},
  year={2010},
  volume={16 1},
  pages={
          10-5
        }
}
  • Marie Cibois, Carole Gautier-Courteille, +1 author Luc Paillard
  • Published in RNA 2010
  • Medicine, Biology
  • Targeted inactivations of RNA-binding proteins (RNA-BPs) can lead to huge phenotypical defects. These defects are due to the deregulation of certain mRNAs. However, we generally do not know, among the hundreds of mRNAs that are normally controlled by one RNA-BP, which are responsible for the observed phenotypes. Here, we designed an antisense oligonucleotide ("target protector") that masks the binding site of the RNA-BP CUG-binding protein 1 (CUGBP1) on the mRNA Suppressor of Hairless [Su(H… CONTINUE READING

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