A strategy for the late-stage divergent syntheses of scyphostatin analogues.

Abstract

This account details the synthesis of two scyphostatin analogues exhibiting a reactive polar epoxycyclohexenone core and various amide side chains outfitted for late-stage chemical derivatization into the desirable lipophilic tails. Our efforts highlight a key ipso-dearomatization process and provide new insights regarding the incompatibility and orthogonal… (More)
DOI: 10.1021/jo102327e

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