A strategy for removing the bias in the graphical analysis method.

  title={A strategy for removing the bias in the graphical analysis method.},
  author={Jean Logan and Joanna S. Fowler and Nora D. Volkow and Yu-Shin Ding and G J Wang and David L. Alexoff},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  volume={21 3},
The graphical analysis method, which transforms multiple time measurements of plasma and tissue uptake data into a linear plot, is a useful tool for rapidly obtaining information about the binding of radioligands used in PET studies. The strength of the method is that it does not require a particular model structure. However, a bias is introduced in the case of noisy data resulting in the underestimation of the distribution volume (DV), the slope obtained from the graphical method. To remove… CONTINUE READING
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