A straightforward approach towards combined α-amino and α-hydroxy acids based on Passerini reactions


Complex amino acids with an α-acyloxycarbonyl functionality in the side chain are easily available through epoxide opening by chelated enolates and subsequent oxidation/Passerini reaction. This protocol works with both, aldehyde and ketone intermediates, as long as the ketones are activated by electron-withdrawing groups. In principle Ugi reactions are also… (More)
DOI: 10.3762/bjoc.7.151


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