A straight path to circular proteins.

  title={A straight path to circular proteins.},
  author={John M. Antos and Maximilian Wei-Lin Popp and Robert Ernst and Guo-Liang Chew and Eric Spooner and Hidde L. Ploegh},
  journal={The Journal of biological chemistry},
  volume={284 23},
Folding and stability are parameters that control protein behavior. The possibility of conferring additional stability on proteins has implications for their use in vivo and for their structural analysis in the laboratory. Cyclic polypeptides ranging in size from 14 to 78 amino acids occur naturally and often show enhanced resistance toward denaturation and proteolysis when compared with their linear counterparts. Native chemical ligation and intein-based methods allow production of circular… CONTINUE READING