A stop transfer sequence recognizes receptors for nascent chain translocation across the endoplasmic reticulum membrane.

Abstract

A stop transfer sequence derived from the extreme carboxyl terminus of membrane IgM heavy chain has been shown to confer predictable transmembrane orientation to secretory proteins by aborting translocation of subsequently synthesized protein domains. Here we demonstrate that, in certain peptide sequence contexts, the same stop transfer sequence is also… (More)

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