A stochastic model of kinetochore–microtubule attachment accurately describes fission yeast chromosome segregation

@inproceedings{Gay2012ASM,
  title={A stochastic model of kinetochore–microtubule attachment accurately describes fission yeast chromosome segregation},
  author={Guillaume Gay and Thibault Courth{\'e}oux and Celine Marie Reyes and Sylvie Tournier and Yannick Gachet},
  booktitle={The Journal of cell biology},
  year={2012}
}
In fission yeast, erroneous attachments of spindle microtubules to kinetochores are frequent in early mitosis. Most are corrected before anaphase onset by a mechanism involving the protein kinase Aurora B, which destabilizes kinetochore microtubules (ktMTs) in the absence of tension between sister chromatids. In this paper, we describe a minimal mathematical model of fission yeast chromosome segregation based on the stochastic attachment and detachment of ktMTs. The model accurately reproduces… CONTINUE READING

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