A stereoselective synthesis of (+)-physoperuvine using a tandem aza-Claisen rearrangement and ring closing metathesis reaction.

@article{Zaed2009ASS,
  title={A stereoselective synthesis of (+)-physoperuvine using a tandem aza-Claisen rearrangement and ring closing metathesis reaction.},
  author={Ahmed M. Zaed and Michael D Swift and Andrew Sutherland},
  journal={Organic & biomolecular chemistry},
  year={2009},
  volume={7 13},
  pages={2678-80}
}
A stereoselective synthesis of (+)-physoperuvine, a tropane alkaloid from Physalis peruviana Linne has been developed using a one-pot tandem aza-Claisen rearrangement and ring closing metathesis reaction to form the key amino-substituted cycloheptene ring.