A stepped care strategy using buprenorphine and methadone versus conventional methadone maintenance in heroin dependence: a randomized controlled trial.

@article{Kakko2007ASC,
  title={A stepped care strategy using buprenorphine and methadone versus conventional methadone maintenance in heroin dependence: a randomized controlled trial.},
  author={Johan Kakko and Leif Gr{\"o}nbladh and Kerstin Dybrandt Svanborg and Joachim von Wachenfeldt and Christian R{\"u}ck and B. Burford Rawlings and Lars-H{\aa}kan Nilsson and Markus Heilig},
  journal={The American journal of psychiatry},
  year={2007},
  volume={164 5},
  pages={797-803}
}
OBJECTIVE Both methadone and buprenorphine are effective therapy for heroin dependence. Efficacy is best documented for methadone maintenance therapy, but safety concerns limit its use. Buprenorphine offers lower overdose risk and improved access, but efficacy may be lower. The authors compared adaptive, buprenorphine-based stepped care to optimal methadone maintenance treatment. METHOD This randomized controlled trial was undertaken 2004-2006. It consisted of a 24-day uniform double-blind… CONTINUE READING