A stem-line model for cellular and chromosomal differentiation in early mouse-development.

  • Melanie Monk
  • Published 1981 in Differentiation; research in biological diversity

Abstract

Differentiation in mouse embryo development is represented formally by means of a stem-line model in which: 1. Individual choices are structured so that only a fraction of the cells of a given population receive a signal to undergo a change of state that results in a departure from the stem line. 2. Development proceeds by a series of restrictions in potency of all the cells in the stem line. 3. The stem line harbours the germ cells. 4. The germ cells are returned to a state of totipotency by some event(s) leading to meiosis.

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@article{Monk1981ASM, title={A stem-line model for cellular and chromosomal differentiation in early mouse-development.}, author={Melanie Monk}, journal={Differentiation; research in biological diversity}, year={1981}, volume={19 2}, pages={71-6} }