A stem cell marker-expressing subset of enteroendocrine cells resides at the crypt base in the small intestine.

@article{Sei2011ASC,
  title={A stem cell marker-expressing subset of enteroendocrine cells resides at the crypt base in the small intestine.},
  author={Yoshitatsu Sei and Xinping Lu and Alice P. Liou and Xilin Zhao and Stephen Wank},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2011},
  volume={300 2},
  pages={G345-56}
}
The spatial orientation of the enteroendocrine cells along the crypt-villus axis is closely associated with their differentiation in the intestine. Here we studied this relationship using primary duodenal crypts and an ex vivo organoid system established from cholecystokinin-green fluorescent protein (CCK-GFP) transgenic mice. In the primary duodenal crypts, GFP+ cells were found not only in the upper crypt but also at the crypt base, where the stem cells reside. Many GFP+ cells below +4… CONTINUE READING

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Immunohistochemical studies indicate multiple enteroendocrine cell differentiation pathways in the mouse proximal small intestine.

Developmental dynamics : an official publication of the American Association of Anatomists • 1994
View 6 Excerpts
Highly Influenced

, respectively

FJ Naya, HP Huang, +4 authors MJ Tsai
2009

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