A stearylated CPP for delivery of splice correcting oligonucleotides using a non-covalent co-incubation strategy.

Abstract

Aberrations in splicing patterns play a significant role in several diseases, and splice correction, together with other forms of gene regulation, is consequently an emerging therapeutic target. In order to achieve successful oligonucleotide transfection, efficient delivery vectors are generally necessary. In this study we present one such vector, the… (More)
DOI: 10.1016/j.jconrel.2008.11.025

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