A statistical thermodynamic model of the protein ensemble.

  title={A statistical thermodynamic model of the protein ensemble.},
  author={Vincent J. Hilser and E BertrandGarc{\'i}a-Moreno and Terrence G. Oas and G. B. Kapp and Steven T. Whitten},
  journal={Chemical reviews},
  volume={106 5},
To understand the structural basis of biology, it is necessary to understand the transformations of macromolecules during functional cycles. These changes can involve large-scale conformational transformations, changes in the state of ligation or association, changes in dynamics, or alterations in covalent bond structure. X-ray crystallography and NMR spectroscopy have been invaluable for the description of the structures of proteins and their transformations. However, proteins are far from… CONTINUE READING


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Publications referenced by this paper.

Protein Struct . , Stab . Folding

V. J. Hilser
Methods Mol . Biol . • 2001

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