A statistical evaluation of toxicity study designs for the estimation of the benchmark dose in continuous endpoints.

@article{Slob2005ASE,
  title={A statistical evaluation of toxicity study designs for the estimation of the benchmark dose in continuous endpoints.},
  author={Wout Slob and Mirjam Moerbeek and Eija Rauniomaa and Aldert H. Piersma},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2005},
  volume={84 1},
  pages={167-85}
}
The benchmark approach is gaining attention as an alternative to the No-Observed-Adverse-Effect-Level (NOAEL) approach. However, current guidelines for the design of toxicity tests are based on assessing a NOAEL. It has been suggested that the current study design may not be optimal for assessing a Benchmark Dose (BMD). To further investigate this we performed three simulation studies in which a large number of designs were compared, focusing on continuous endpoints. Four fictitious endpoints… CONTINUE READING

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