A statistical approach for array CGH data analysis

  title={A statistical approach for array CGH data analysis},
  author={Franck Picard and St{\'e}phane Robin and Marc Lavielle and Christian Vaisse and Jean-Jacques Daudin},
  journal={BMC Bioinformatics},
  pages={27 - 27}
Microarray-CGH experiments are used to detect and map chromosomal imbalances, by hybridizing targets of genomic DNA from a test and a reference sample to sequences immobilized on a slide. These probes are genomic DNA sequences (BACs) that are mapped on the genome. The signal has a spatial coherence that can be handled by specific statistical tools. Segmentation methods seem to be a natural framework for this purpose. A CGH profile can be viewed as a succession of segments that represent… CONTINUE READING
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