A static, closed and scaffold-free bioreactor system that permits chondrogenesis in vitro.

@article{Grogan2003ASC,
  title={A static, closed and scaffold-free bioreactor system that permits chondrogenesis in vitro.},
  author={Shawn Patrick Grogan and Franz Rieser and Verena Winkelmann and Simona Berardi and Pierre Mainil-Varlet},
  journal={Osteoarthritis and cartilage},
  year={2003},
  volume={11 6},
  pages={403-11}
}
OBJECTIVE To characterise in vitro engineered cartilaginous constructs made employing a novel static, scaffold-free and closed chamber system. DESIGN Chondrocytes derived from slaughter age pigs (3-6 months) were seeded at high density (20 x 10(6)) into cylindrical chambers (1.0 x 0.5cm) and were maintained between an upper and a lower membrane (100 kDa) for 21 days and subsequently cultured in open culture for 7 additional days. RESULTS Viable constructs produced were approximately 10… CONTINUE READING

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