A stat-responsive element in the promoter of the episialin/MUC1 gene is involved in its overexpression in carcinoma cells.

@article{Gaemers2001ASE,
  title={A stat-responsive element in the promoter of the episialin/MUC1 gene is involved in its overexpression in carcinoma cells.},
  author={Ingrid C. Gaemers and Hans L. Vos and Haukeline H. Volders and S W van der Valk and John Hilkens},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 9},
  pages={6191-9}
}
The mucin-like glycoprotein episialin (MUC1) is highly overproduced by a number of human carcinomas. We have shown previously in a variety of mammalian cell lines that overexpression of this very large transmembrane molecule diminishes cellular adhesion, suggesting that episialin/MUC1 overexpression may play an important role in tumor invasion and metastasis. By using in situ hybridization, we show here that episialin/MUC1 mRNA expression can be increased more than 10-fold in breast carcinoma… CONTINUE READING