A standardized root extract of Withania somnifera and its major constituent withanolide-A elicit humoral and cell-mediated immune responses by up regulation of Th1-dominant polarization in BALB/c mice.

@article{Malik2007ASR,
  title={A standardized root extract of Withania somnifera and its major constituent withanolide-A elicit humoral and cell-mediated immune responses by up regulation of Th1-dominant polarization in BALB/c mice.},
  author={Fayaz Ahmed Malik and Jaswant Singh and Anamika Khajuria and Krishan Avtar Suri and Naresh Kumar Satti and Surjeet Singh and Maharaj K. Kaul and Arun Kumar and Aruna Bhatia and Ghulam Nabi Qazi},
  journal={Life sciences},
  year={2007},
  volume={80 16},
  pages={1525-38}
}
The effects of graded doses of a chemically standardized aqueous alcoholic (1:1) root extract (AGB) of Withania somnifera on the immune system of SRBC immunized BALB/c mice were investigated. Mice were administrated AGB orally for 15 days. AGB stimulated cell mediated immunity, IgM and IgG titers reaching peak value with 30 mg/kg b.wt. Flow cytometric analysis of lymphocyte surface markers of T cells (CD3(+), CD4(+) and CD8(+)) and B cells (CD19(+)) indicated prominent enhancement in… CONTINUE READING
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