A standardized methodical approach to characterize the influence of key parameters on the in vitro efficacy of extracorporeal photopheresis

@inproceedings{Laulh2019ASM,
  title={A standardized methodical approach to characterize the influence of key parameters on the in vitro efficacy of extracorporeal photopheresis},
  author={Marie Laulh{\'e} and Sylvie Lef{\`e}bvre and Delphine Le Broc-Ryckewaert and M Vincent Pierre and Aur{\'e}lie Ferry and Bruno Delorme},
  booktitle={PloS one},
  year={2019}
}
Extracorporeal photopheresis (ECP) is an autologous immunomodulatory cell therapy that consists of the ex vivo collection of mononuclear cells (MNCs), which are irradiated with UVA in the presence of the photosensitizing agent 8-methoxypsoralen (8-MOP) to induce cell apoptosis. This photoactivated cell preparation is then reinfused into the patient. While the clinical benefits of ECP are well-demonstrated, no study has yet characterized the influence of variations in the composition of the cell… CONTINUE READING
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