A standardized animal model for evaluation of hemostatic effectiveness of various materials.

@article{Chvapil1983ASA,
  title={A standardized animal model for evaluation of hemostatic effectiveness of various materials.},
  author={Milos Chvapil and John Alexander Owen and Donald W. Deyoung},
  journal={The Journal of trauma},
  year={1983},
  volume={23 12},
  pages={1042-7}
}
Two anatomic sites of bleeding injuries were selected in dogs to evaluate the hemostatic effectiveness and handling properties of various hemostatic materials. Split-thickness skin excisions inflict a wound of 90 cm2 area with regular spotted bleeding, which allows gravimetric quantitation of blood loss and of ease of removal of the agent. Excision of a wedge of the spleen 0.5 cm deep and 4 cm wide induced reproducible and moderate bleeding in pentobarbital-anesthesized dogs. Three to four… CONTINUE READING

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