A stable system for the high-titer production of multiply attenuated lentiviral vectors.

@article{Klages2000ASS,
  title={A stable system for the high-titer production of multiply attenuated lentiviral vectors.},
  author={Natacha Klages and Romain Zufferey and Didier Trono},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2000},
  volume={2 2},
  pages={170-6}
}
Lentiviral vectors open exciting perspectives for the genetic treatment of a wide array of inherited and acquired diseases, owing to their ability to govern the efficient delivery, integration, and long-term expression of transgenes into nondividing cells both in vitro and in vivo. The genomic complexity of HIV, where a whole set of genes encode virulence factors essential for pathogenesis but not required for gene transfer, allowed a major step toward clinical acceptability through the… CONTINUE READING

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