A stable proportion of Lewy body bearing neurons in the substantia nigra suggests a model in which the Lewy body causes neuronal death

@article{Greffard2010ASP,
  title={A stable proportion of Lewy body bearing neurons in the substantia nigra suggests a model in which the Lewy body causes neuronal death},
  author={Sandrine Greffard and Marc Verny and Anne-Marie Bonnet and Danielle Seilhean and Charles Duyckaerts},
  journal={Neurobiology of Aging},
  year={2010},
  volume={31},
  pages={99-103}
}
Lewy bodies in Parkinson disease could be innocent bystanders or active agents responsible for neuronal death. Eighteen elderly patients with a Parkinson syndrome were studied prospectively and selected postmortem on the presence of Lewy bodies (14 cases with Parkinson disease, four with dementia with Lewy bodies). Information on disease duration was available in 17 cases. While akinesia and rigidity were linked with the neuronal loss, the percentages of Lewy body bearing neurons and of alpha… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 11 REFERENCES

Lewy bodyrelated alphasynucleinopathy in aging

  • C. chwab, M. Schulzer, J. C. Steele, P. L. McGeer
  • J . Neuropathol . Exp . Neurol .
  • 2004

The neuromythology of Parkinson ’ s disease

  • Y. Mizuno
  • Parkinsonism Relat . Disord .
  • 2004
2 Excerpts

The role of the Lewy body in idiopathic Parkinsonism

  • R. e la Fuente-Fernandez, M. Schulzer, E. Mak, A. Kishore, D. B. Calne
  • Parkinson - ism Relat . Disord .
  • 1998

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