A stable model of respiratory distress by small injections of oleic acid in pigs

@article{Grotjohan1996ASM,
  title={A stable model of respiratory distress by small injections of oleic acid in pigs},
  author={H. P. Grotjohan and R. M. J. L. van der Heijde and Jos R. C. Jansen and C. A. Wagenvoort and Adrian Versprille},
  journal={Intensive Care Medicine},
  year={1996},
  volume={22},
  pages={336-344}
}
Development of a stable model of respiratory distress in pigs with oleic acid, fulfilling clinical criteria of the adult respiratory distress syndrome (ARDS). Eight pigs (9.1±0.7 kg) were anesthetized with pentobarbital, paralyzed with tubocurarine and mechanically ventilated with an $$F_{IO_2 } $$ of 0.6, an I∶E ratio of 2∶3 and a PEEP of 0.2 kPa. Oleic acid (dissolved 1∶1 in 96% alcohol) was administered in a series of multiple injections of 0.1 ml until $$P_{aO_2 } $$ was lower than 8 kPa… CONTINUE READING

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