A stable and selective electrochemical biosensor for the liver enzyme alanine aminotransferase (ALT).

@article{Jamal2009ASA,
  title={A stable and selective electrochemical biosensor for the liver enzyme alanine aminotransferase (ALT).},
  author={M. M. El Jamal and Oliver Worsfold and Timothy McCormac and Eithne Dempsey},
  journal={Biosensors & bioelectronics},
  year={2009},
  volume={24 9},
  pages={2926-30}
}
An electrochemical method to determine alanine aminotransferase (ALT) activity over its normal and elevated physiological range was developed based upon detection of L-glutamate at a glutamate oxidase-modified platinum electrode. Measurements were carried out in the presence of ALT co-substrates L-alanine and alpha-ketoglutarate and current response from either the oxidation of hydrogen peroxide or the re-oxidation of the mediator ferrocene carboxylic acid was employed. The enzyme electrode was… CONTINUE READING

Similar Papers

Loading similar papers…