A stabilizer-free and organic solvent-free method to prepare 10-hydroxycamptothecin nanocrystals: in vitro and in vivo evaluation

@inproceedings{Yang2016ASA,
  title={A stabilizer-free and organic solvent-free method to prepare 10-hydroxycamptothecin nanocrystals: in vitro and in vivo evaluation},
  author={Xiaofeng Yang and Yingying Liu and Yanna Zhao and Xiangtao Wang and Yifei Guo and HaiXue Kuang},
  booktitle={International journal of nanomedicine},
  year={2016}
}
10-Hydroxycamptothecin (10-HCPT) is a promising anticancer drug with a wide spectrum of antitumor activities. Due to its poor solubility, the carboxylate form that shows high water solubility but minimal anticancer activity and pharmacokinetic defects is used in the marketed 10-HCPT injections, resulting in its limited clinical application. To develop a simple, safe, and highly effective drug delivery system, a modified acid-base microprecipitation combined with a high-pressure homogenization… CONTINUE READING
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