A spontaneous mutation involving Kcnq2 (Kv7.2) reduces M-current density and spike frequency adaptation in mouse CA1 neurons.

@article{Otto2006ASM,
  title={A spontaneous mutation involving Kcnq2 (Kv7.2) reduces M-current density and spike frequency adaptation in mouse CA1 neurons.},
  author={James F. Otto and Yan Yang and Wayne N. Frankel and Henry S White and Karen S. Wilcox},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2006},
  volume={26 7},
  pages={
          2053-9
        }
}
The M-type K+ current [IK(M)] activates in response to membrane depolarization and regulates neuronal excitability. Mutations in two subunits (KCNQ2 and KCNQ3; Kv7.2 and Kv7.3) that underlie the M-channel cause the human seizure disorder benign familial neonatal convulsions (BFNC), presumably by reducing IK(M) function. In mice, the Szt1 mutation, which deletes the genomic DNA encoding the KCNQ2 C terminus and all of CHRNA4 (nicotinic acetylcholine receptor alpha4 subunit) and ARFGAP-1 (GTPase… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 36 CITATIONS

β-Secretase BACE1 regulates hippocampal and reconstituted M-currents in a β-subunit-like fashion.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2015
VIEW 7 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Somatostatin receptor subtype 4 couples to the M-current to regulate seizures.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2008
VIEW 3 EXCERPTS
CITES RESULTS
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 37 REFERENCES

Differential tetraethylammonium sensitivity of KCNQ1-4 potassium channels.

  • British journal of pharmacology
  • 2000
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Genetic mechanisms that underlie epilepsy

  • Nature Reviews Neuroscience
  • 2004
VIEW 2 EXCERPTS

Similar Papers

Loading similar papers…