A spinosyn-sensitive Drosophila melanogaster nicotinic acetylcholine receptor identified through chemically induced target site resistance, resistance gene identification, and heterologous expression.

@article{Watson2010ASD,
  title={A spinosyn-sensitive Drosophila melanogaster nicotinic acetylcholine receptor identified through chemically induced target site resistance, resistance gene identification, and heterologous expression.},
  author={Gerald B Watson and Scott W Chouinard and Kevin R Cook and Chaoxian Geng and Jim M Gifford and Gary D Gustafson and James M Hasler and Ignacio M. Larrinua and Ted J Letherer and Jon C. Mitchell and William L. Pak and Vincent L. Salgado and Thomas C. Sparks and Geoff E Stilwell},
  journal={Insect biochemistry and molecular biology},
  year={2010},
  volume={40 5},
  pages={376-84}
}
Strains of Drosophila melanogaster with resistance to the insecticides spinosyn A, spinosad, and spinetoram were produced by chemical mutagenesis. These spinosyn-resistant strains were not cross-resistant to other insecticides. The two strains that were initially characterized were subsequently found to have mutations in the gene encoding the nicotinic acetylcholine receptor (nAChR) subunit Dalpha6. Subsequently, additional spinosyn-resistant alleles were generated by chemical mutagenesis and… CONTINUE READING

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