A spindle-like apparatus guides bacterial chromosome segregation

@article{Ptacin2010ASA,
  title={A spindle-like apparatus guides bacterial chromosome segregation},
  author={Jerod L. Ptacin and Steven F Lee and Ethan C Garner and Esteban Toro and Michael Eckart and Luis R. Comolli and W E Moerner and Lucy Shapiro},
  journal={Nature Cell Biology},
  year={2010},
  volume={12},
  pages={791-798}
}
Until recently, a dedicated mitotic apparatus that segregates newly replicated chromosomes into daughter cells was believed to be unique to eukaryotic cells. Here we demonstrate that the bacterium Caulobacter crescentus segregates its chromosome using a partitioning (Par) apparatus that has surprising similarities to eukaryotic spindles. We show that the C. crescentus ATPase ParA forms linear polymers in vitro and assembles into a narrow linear structure in vivo. The centromere-binding protein… CONTINUE READING
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