A spindle assembly checkpoint protein functions in prophase I arrest and prometaphase progression.

@article{Homer2009ASA,
  title={A spindle assembly checkpoint protein functions in prophase I arrest and prometaphase progression.},
  author={Hayden Homer and Liming Gui and John R. Carroll},
  journal={Science},
  year={2009},
  volume={326 5955},
  pages={991-4}
}
Two critical stages of mammalian oocyte regulation are prophase I arrest, which is important for sustaining the oocyte pool, and the progression through meiosis I (MI) to produce fertilizable eggs. We have found that the spindle assembly checkpoint protein BubR1 regulates both stages in mouse oocytes. We show that oocytes depleted of BubR1 cannot sustain prophase I arrest and readily undergo germinal vesicle breakdown, a marker for reentry into MI. BubR1-depleted oocytes then arrest before… CONTINUE READING