A spider toxin (JSTX) inhibits l-glutamate uptake by rat brain synaptosomes

@article{PanHou1989AST,
  title={A spider toxin (JSTX) inhibits l-glutamate uptake by rat brain synaptosomes},
  author={H. Pan-Hou and Y. Suda and M. Sumi and M. Yoshioka and N. Kawai},
  journal={Brain Research},
  year={1989},
  volume={476},
  pages={354-357}
}
Joro spider toxin (JSTX), a specific blocker of glutamate receptors, was found to exert a prominent suppressive action on the Na+-dependent binding of L-glutamate to synaptic membranes and on glutamate uptake by synaptosomes in a dose-dependent manner. In contrast, the synthesized 2,4-dihydroxyphenylacetylasparagine (2,4-DHPA-ASN), a common moiety of spider toxins, which has been shown to exhibit almost the same activity as intact JSTX with respect to the inhibition of Na+-independent glutamate… Expand
Neuroactive Toxins of Spider Venoms
The glutamatergic nerve terminal.
  • D. Nicholls
  • Biology, Medicine
  • European journal of biochemistry
  • 1993
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