A sphingosine 1-phosphate receptor 2 selective allosteric agonist.

@article{Satsu2013AS1,
  title={A sphingosine 1-phosphate receptor 2 selective allosteric agonist.},
  author={H. Satsu and M. Schaeffer and M. Guerrero and Adrian Saldana and Christina Eberhart and P. Hodder and C. Cayanan and S. Sch{\"u}rer and B. Bhhatarai and E. Roberts and H. Rosen and S. Brown},
  journal={Bioorganic \& medicinal chemistry},
  year={2013},
  volume={21 17},
  pages={
          5373-82
        }
}
Molecular probe tool compounds for the Sphingosine 1-phosphate receptor 2 (S1PR2) are important for investigating the multiple biological processes in which the S1PR2 receptor has been implicated. Amongst these are NF-κB-mediated tumor cell survival and fibroblast chemotaxis to fibronectin. Here we report our efforts to identify selective chemical probes for S1PR2 and their characterization. We employed high throughput screening to identify two compounds which activate the S1PR2 receptor. SAR… Expand
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References

SHOWING 1-10 OF 32 REFERENCES
Sphingosine 1-Phosphate Analogs as Receptor Antagonists*
Novel selective allosteric and bitopic ligands for the S1P(3) receptor.
Sphingosine 1-phosphate receptor signaling.
Identification of Edg1 Receptor Residues That Recognize Sphingosine 1-Phosphate*
Crystal Structure of a Lipid G Protein–Coupled Receptor
...
1
2
3
4
...