A speed limit for conformational change of an allosteric membrane protein.

@article{Chakrapani2005ASL,
  title={A speed limit for conformational change of an allosteric membrane protein.},
  author={Sudha Chakrapani and Anthony Auerbach},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 1},
  pages={87-92}
}
Neuromuscular acetylcholine receptors are synaptic ion channels that open and close with rate constants of approximately equal to 48,000 s(-1) and approximately equal to 1,700 s(-1), respectively (in adult mouse, at 24 degrees C, -100 mV membrane potential). Perturbations of many different sites in the protein can change these rate constants, with those in the extracellular domain mainly affecting channel-opening and many of those in the membrane and intracellular domains mainly affecting… CONTINUE READING
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Rates and Equilibria of Organic Reactions (Wiley, New York)

  • J. E. Leffler, E. Grunwald
  • 1963

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